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Article

The mitochondrial DNA control region shows genetically correlated levels of heteroplasmy in leukocytes of centenarians and their offspring.

BMC genomics - 29 Aug 2007

Rose Giuseppina, Passarino Giuseppe, Scornaienchi Vittorio, Romeo Giuseppe, Dato Serena, Bellizzi Dina, Mari Vincenzo, Feraco Emidio, Maletta Raffaele, Bruni Amalia, Franceschi Claudio, De Benedictis Giovanna

Abstract excerpt

BACKGROUND: Studies on heteroplasmy occurring in the mitochondrial DNA (mtDNA) control region (CR) in leukocytes of centenarians and younger subjects have shown that the C150T somatic transition is over-represented in centenarians. However, whether the occurrence/accumulation of heteroplasmy is a phenotypic consequence of extreme ageing or a genetically controlled event that may favor longevity is a question that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17727699
DOI: 10.1186/1471-2164-8-293
PMCID: PMC2014781

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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