Article
A combination of three common inherited mitochondrial DNA polymorphisms promotes longevity in Finnish and Japanese subjects.
European journal of human genetics : EJHG - 1 Feb 2005
Niemi Anna-Kaisa, Moilanen Jukka S, Tanaka Masashi, Hervonen Antti, Hurme Mikko, Lehtimäki Terho, Arai Yasumichi, Hirose Nobuyoshi, Majamaa Kari
Abstract excerpt
Mitochondrial DNA (mtDNA) coding region polymorphisms, as well as the 150T polymorphism in the noncoding region, have been associated with longevity. We have studied here the association of 150T with longevity further and assessed differences in this association between various mtDNA haplogroups. We analysed a sample of 321 very old subjects and 489 middle-aged controls from Finland and Japan. 150T was more...
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