Decreased reactive oxygen species production in cells with mitochondrial haplogroups associated with longevity.

doi:10.1371/journal.pone.0046473

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Article

Decreased reactive oxygen species production in cells with mitochondrial haplogroups associated with longevity.

PloS one - 1 Jan 2012

Chen Ai, Raule Nicola, Chomyn Anne, Attardi Giuseppe

Abstract excerpt

Mitochondrial DNA (mtDNA) is highly polymorphic, and its variations in humans may contribute to individual differences in function. Zhang and colleagues found a strikingly higher frequency of a C150T transition in the D-loop of mtDNA from centenarians and twins of an Italian population, and also demonstrated that this base substitution causes a remodeling of the mtDNA 151 replication origin in human leukocytes...

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Identifiers

PMID: 23144696
DOI: 10.1371/journal.pone.0046473
PMCID: PMC3483264

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.