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Variations at the H-strand replication origins of mitochondrial DNA and mitochondrial DNA content in the blood of type 2 diabetes patients.

Biochimica et biophysica acta - 1 May 2009

Cormio Antonella, Milella Francesco, Marra Maurizio, Pala Maria, Lezza Angela Maria Serena, Bonfigli Anna Rita, Franceschi Claudio, Cantatore Palmiro, Gadaleta Maria Nicola

Abstract excerpt

Mitochondrial DNA (mtDNA) sequence variation in the segment of the D-loop region encompassing the initiation sites for replication and transcription was analyzed in the blood of 277 Italian type 2 diabetes patients and 277 Italian healthy subjects. Compared with the Cambridge Reference Sequence, diabetic patients show a slightly higher propensity to accumulate base changes in this region, with respect to...

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Identifiers

PMID: 19344660
DOI: 10.1016/j.bbabio.2009.01.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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