Whole-genome sequencing analysis of semi-supercentenarians.

doi:10.7554/eLife.57849

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Article

Whole-genome sequencing analysis of semi-supercentenarians.

eLife - 4 May 2021

Garagnani Paolo, Marquis Julien, Delledonne Massimo, Pirazzini Chiara, Marasco Elena, Kwiatkowska Katarzyna Malgorzata, Iannuzzi Vincenzo, Bacalini Maria Giulia, Valsesia Armand, Carayol Jerome, Raymond Frederic, Ferrarini Alberto, Xumerle Luciano, Collino Sebastiano, Mari Daniela, Arosio Beatrice, Casati Martina, Ferri Evelyn, Monti Daniela, Nacmias Benedetta, Sorbi Sandro, Luiselli Donata, Pettener Davide, Castellani Gastone, Sala Claudia, Passarino Giuseppe, De Rango Francesco, D'Aquila Patrizia, Bertamini Luca, Martinelli Nicola, Girelli Domenico, Olivieri Oliviero, Giuliani Cristina, Descombes Patrick, Franceschi Claudio

Abstract excerpt

Extreme longevity is the paradigm of healthy aging as individuals who reached the extreme decades of human life avoided or largely postponed all major age-related diseases. In this study, we sequenced at high coverage (90X) the whole genome of 81 semi-supercentenarians and supercentenarians [105+/110+] (mean age: 106.6 ± 1.6) and of 36 healthy unrelated geographically matched controls (mean age 68.0 ± 5.9)...

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Identifiers

PMID: 33941312
DOI: 10.7554/eLife.57849
PMCID: PMC8096429

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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