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Article

Unique resistance of I/LnJ mice to a retrovirus is due to sustained interferon gamma-dependent production of virus-neutralizing antibodies.

The Journal of experimental medicine - 20 Jan 2003

Purdy Alexandra, Case Laure, Duvall Melody, Overstrom-Coleman Max, Monnier Nilah, Chervonsky Alexander, Golovkina Tatyana

Abstract excerpt

Selection of immune escape variants impairs the ability of the immune system to sustain an efficient antiviral response and to control retroviral infections. Like other retroviruses, mouse mammary tumor virus (MMTV) is not efficiently eliminated by the immune system of susceptible mice. In contrast, MMTV-infected I/LnJ mice are capable of producing IgG2a virus-neutralizing antibodies, sustain this response...

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Identifiers

PMID: 12538662
DOI: 10.1084/jem.20021499
PMCID: PMC2193815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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