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Article

High mutant frequency in populations of a DNA virus allows evasion from antibody therapy in an immunodeficient host.

Journal of virology - 1 Feb 2003

López-Bueno Alberto, Mateu Mauricio G, Almendral José M

Abstract excerpt

The degree of genetic heterogeneity of DNA virus populations in nature and its consequences for disease control are virtually unknown. The parvovirus minute virus of mice (MVMi) was used here to investigate (i) the frequency of antibody-escape mutants in populations of a DNA virus and (ii) the ability of a DNA virus to evade in the long-term a passive monoclonal antibody (MAb) therapy in an immunodeficient...

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Share to Antibodies, Monoclonal
Share to Antibodies, Viral
Share to Capsid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunization, Passive

Share to Mice, SCID

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Share to Parvoviridae Infections

Source

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Identifiers

PMID: 12552010
DOI: 10.1128/jvi.77.4.2701-2708.2003
PMCID: PMC141124

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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