Article
Characterization of interferon-γ-treated melanoma tumor cells for use in dendritic cell-based immunotherapy.
Cancer biotherapy & radiopharmaceuticals - 1 Jun 2011
Cornforth Andrew N, Fowler Abner W, Carbonell Denysha J, Fan Eric, Dillman Robert O
Abstract excerpt
Efficient delivery of tumor-associated antigens to professional antigen-presenting cells is important for inducing a response in patients receiving cancer immunotherapy. Interferon-gamma (IFN-γ) is used by the immune system to combat viral and fungal infections by restricting cell proliferation and, in some cases, inducing apoptosis. Using IFN-γ to activate target tumor cells prior to antigen loading of dendritic...
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