Effects of cyclophosphamide and IL-2 on regulatory CD4+ T cell frequency and function in melanoma patients vaccinated with HLA-class I peptides: impact on the antigen-specific T cell response.

doi:10.1007/s00262-013-1397-7

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Article

Effects of cyclophosphamide and IL-2 on regulatory CD4+ T cell frequency and function in melanoma patients vaccinated with HLA-class I peptides: impact on the antigen-specific T cell response.

Cancer immunology, immunotherapy : CII - 1 May 2013

Camisaschi Chiara, Filipazzi Paola, Tazzari Marcella, Casati Chiara, Beretta Valeria, Pilla Lorenzo, Patuzzo Roberto, Maurichi Andrea, Cova Agata, Maio Michele, Chiarion-Sileni Vanna, Tragni Gabrina, Santinami Mario, Vergani Barbara, Villa Antonello, Berti Emilio, Umansky Ludmila, Beckhove Philipp, Umansky Viktor, Parmiani Giorgio, Rivoltini Licia, Castelli Chiara

Abstract excerpt

The frequency and function of regulatory T cells (Tregs) were studied in stage II-III melanoma patients who were enrolled in a phase II randomized trial of vaccination with HLA-A*0201-modified tumor peptides versus observation. The vaccinated patients received low-dose cyclophosphamide (CTX) and low-dose interleukin-2 (IL-2). Tregs were analyzed in the lymph nodes (LNs) of stage III patients who were undergoing...

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PMID: 23589107
DOI: 10.1007/s00262-013-1397-7
PMCID: PMC3634989

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