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Article

Human DNA methyltransferase gene DNMT1 is regulated by the APC pathway.

Carcinogenesis - 1 Jan 2003

Campbell Paul M, Szyf Moshe

Abstract excerpt

Epigenomic changes in DNA methylation patterns are evident in a variety of cancers, including colorectal cancer (CRC). In addition, a large proportion of CRC tumors and cell lines harbor genetic mutations in the APC/beta-catenin/TCF transcription activation pathway. While several target genes have been proposed, a causal downstream agent between APC mutation and cancer has not been fully established. Because...

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Source

Identifiers

PMID: 12538344
DOI: 10.1093/carcin/24.1.17

Genes

DNMT1
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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