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Article

Mutation of the DNA methyltransferase (DNMT) 1 gene in human colorectal cancers.

Cancer letters - 20 Mar 2003

Kanai Yae, Ushijima Saori, Nakanishi Yukihiro, Sakamoto Michiie, Hirohashi Setsuo

Abstract excerpt

Alteration of DNA methylation is one of the most consistent epigenetic changes in human cancers. DNA methyltransferase (DNMT) 1 is a major enzyme that determines genomic methylation patterns. In order to understand the significance of mutations of the DNMT1 gene during human carcinogenesis, we performed polymerase chain reaction-single strand conformation polymorphism analysis using 46 oligonucleotide primer sets...

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Source

Identifiers

PMID: 12637155
DOI: 10.1016/s0304-3835(02)00689-4

Genes

DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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