Article
High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer.
15 Apr 1991
Abstract excerpt
DNA methylation abnormalities occur consistently in human neoplasia including widespread hypomethylation and more recently recognized local increases in DNA methylation that hold potential for gene inactivation events. To study this imbalance further, we have cloned and localized to chromosome 19 a portion of the human DNA methyltransferase gene that codes for the enzyme catalyzing DNA methylation. Expression of...