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Article

Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice.

Carcinogenesis - 1 Jan 2003

Trasler Jacquetta, Deng Liyuan, Melnyk Stepan, Pogribny Igor, Hiou-Tim Francois, Sibani Sahar, Oakes Christopher, Li En, James S Jill, Rozen Rima

Abstract excerpt

Although a number of studies have suggested that diets with low intake of folate, an important methyl donor, are associated with increased risks of colon cancer and its precursor the adenomatous polyp, the underlying mechanisms are poorly understood. Dysregulation and instability of DNA methylation and alterations in the levels of the predominant DNA methylating enzyme, DNA (cytosine-5)-methyltransferase 1...

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Identifiers

PMID: 12538347
DOI: 10.1093/carcin/24.1.39

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice.PMID 12538347Read ↗

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