TET1 and TDG Suppress Inflammatory Response in Intestinal Tumorigenesis: Implications for Colorectal Tumors With the CpG Island Methylator Phenotype.

doi:10.1053/j.gastro.2023.01.039

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Article

TET1 and TDG Suppress Inflammatory Response in Intestinal Tumorigenesis: Implications for Colorectal Tumors With the CpG Island Methylator Phenotype.

Gastroenterology - 1 May 2023

Tricarico Rossella, Madzo Jozef, Scher Gabrielle, Cohen Maya, Jelinek Jaroslav, Maegawa Shinji, Nagarathinam Rajeswari, Scher Carly, Chang Wen-Chi, Nicolas Emmanuelle, Slifker Michael, Zhou Yan, Devarajan Karthik, Cai Kathy Q, Kwok Tim, Nakajima Pamela, Xu Jinfei, Mancuso Pietro, Doneddu Valentina, Bagella Luigi, Williams Riley, Balachandran Siddharth, Maskalenko Nicholas, Campbell Kerry, Ma Xueying, Cañadas Israel, Viana-Errasti Julen, Moreno Victor, Valle Laura, Grivennikov Sergei, Peshkova Iuliia, Kurilenko Natalia, Mazitova Aleksandra, Koltsova Ekaterina, Lee Hayan, Walsh Martin, Duttweiler Reuben, Whetstine Johnathan R, Yen Timothy J, Issa Jean-Pierre, Bellacosa Alfonso

Abstract excerpt

BACKGROUND & AIMS: Aberrant DNA methylation is frequent in colorectal cancer (CRC), but underlying mechanisms and pathologic consequences are poorly understood. METHODS: We disrupted active DNA demethylation genes Tet1 and/or Tdg from ApcMin mice and characterized the methylome and transcriptome of colonic adenomas. Data were compared to human colonic adenocarcinomas (COAD) in The Cancer Genome Atlas. RESULTS:...

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PMID: 36764492
DOI: 10.1053/j.gastro.2023.01.039
PMCID: PMC10586516

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