Article
Expression and regulation of the transcriptional repressor ZNF43 in Ewing sarcoma cells.
Pediatric pathology & molecular medicine - 1 Jan 2000
González-Lamuño Domingo, Loukili Noureddine, García-Fuentes Miguel, Thomson Timothy M
Abstract excerpt
In vitro, cells derived from Ewing sarcoma (ES) with the characteristic somatic rearrangement between the genes EWS and FLII can be induced to differentiate toward a neuronal phenotype by exposure to agents such as dibutyryl cyclic AMP (db cAMP) or retinoic acid. Therefore, expression of the chimeric Ews-Flil protein does not irreversibly block the capacity of Ewing cells to engage in the neuronal differentiation...
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