Article
Mutations of the D310 mitochondrial mononucleotide repeat in primary tumors and cytological specimens.
Cancer letters - 10 Feb 2003
Parrella Paola, Seripa Davide, Matera Maria Giovanna, Rabitti Carla, Rinaldi Monica, Mazzarelli Paola, Gravina Carolina, Gallucci Michele, Altomare Vincenzo, Flammia Gerardo, Casalino Beniamino, Benedetti-Panici Pier Luigi, Fazio Vito M
Abstract excerpt
A mononucleotide repeat (D310) in mitochondrial DNA has been recently identified as a mutational hot spot in primary tumors. We analyzed 56 tumors for insertion/deletion mutations in the D310 repeat. A total of 13 mutations were detected. The highest frequency of mutations was found for cervical cancer, followed by bladder tumors, breast cancer and endometrial neoplasia. No alterations were observed in four...
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