Article
Facile detection of mitochondrial DNA mutations in tumors and bodily fluids.
Science (New York, N.Y.) - 17 Mar 2000
Fliss M S, Usadel H, Caballero O L, Wu L, Buta M R, Eleff S M, Jen J, Sidransky D
Abstract excerpt
Examination of human bladder, head and neck, and lung primary tumors revealed a high frequency of mitochondrial DNA (mtDNA) mutations. The majority of these somatic mutations were homoplasmic in nature, indicating that the mutant mtDNA became dominant in tumor cells. The mutated mtDNA was readily detectable in paired bodily fluids from each type of cancer and was 19 to 220 times as abundant as mutated nuclear p53...
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