Article
Mitochondrial D-Loop instability in thyroid tumours is not a marker of malignancy.
Mitochondrion - 1 Oct 2005
Máximo Valdemar, Lima Jorge, Soares Paula, Botelho Tiago, Gomes Lígia, Sobrinho-Simões Manuel
Abstract excerpt
Despite the numerous studies describing a high frequency of mitochondrial DNA (mtDNA) somatic mutations in many types of human primary tumors the mechanisms that generate such mutations and the role of mtDNA mutations in tumor development remain unclear. We present the results obtained in the study of mtDNA displacement-loop (D-Loop) region in a series of 66 thyroid tumors, and respective adjacent parenchyma,...
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