Article
Current aspects of hepatitis B surface antigen mutants in Singapore.
Journal of viral hepatitis - 1 Nov 1998
Oon C J, Chen W N
Abstract excerpt
Mutations occurring on the major antigenic 'a' determinant of hepatitis B surface antigen (HBsAg) have been detected in immunized Singapore children, despite immunoprophylaxis with hepatitis B immune globulin and HBV vaccine. These vaccine-escape HBsAg mutants display a predominance of the Gly145-to-Arg145 mutation in the antigenic 'a' determinant. Our latest follow-up studies indicate the stability of this as...
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