Article

BECC-engineered live-attenuated Shigella vaccine candidates display reduced endotoxicity with robust immunogenicity in mice

2024-06-11

Abstract excerpt

<title>Abstract</title> Shigella spp. infection contributes significantly to the global disease burden, primarily affecting young children in developing countries. Currently, there are no FDA-approved vaccines against Shigella, and the prevalence of antibiotic resistance is increasing, making therapeutic options limited. Live-attenuated vaccine strains WRSs2 (S. sonnei) and WRSf2G12 (S. flexneri 2a) are highly...

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Literature Corpus work: 806a45c7-ec7a-5577-b5a5-3da3ab580c94
DOI: 10.21203/rs.3.rs-4448907/v1

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