Article
Construction, genotypic and phenotypic characterization, and immunogenicity of attenuated DeltaguaBA Salmonella enterica serovar Typhi strain CVD 915.
Infection and immunity - 1 Aug 2001
Wang J Y, Pasetti M F, Noriega F R, Anderson R J, Wasserman S S, Galen J E, Sztein M B, Levine M M
Abstract excerpt
A promising live attenuated typhoid vaccine candidate strain for mucosal immunization was developed by introducing a deletion in the guaBA locus of pathogenic Salmonella enterica serovar Typhi strain Ty2. The resultant DeltaguaBA mutant, serovar Typhi CVD 915, has a gene encoding resistance to arsenite replacing the deleted sequence within guaBA, thereby providing a marker to readily identify the vaccine strain....
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- Animals
- Cell Division
- Consumer Product Safety
- Culture Media
- Female
- Genetic Engineering