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Two budding yeast RAD4 homologs in fission yeast play different roles in the repair of UV-induced DNA damage.

DNA repair - 1 Oct 2002

Fukumoto Yasunori, Hiyama Hideki, Yokoi Masayuki, Nakaseko Yukinobu, Yanagida Mitsuhiro, Hanaoka Fumio

Abstract excerpt

We have identified two fission yeast homologs of budding yeast Rad4 and human xeroderma pigmentosum complementation group C (XP-C) correcting protein, designated Rhp4A and Rhp4B. Here we show that the rhp4 genes encode NER factors that are required for UV-induced DNA damage repair in fission yeast. The rhp4A-deficient cells but not the rhp4B-deficient cells are sensitive to UV irradiation. However, the disruption...

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PMID: 12531030
DOI: 10.1016/s1568-7864(02)00108-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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