Article
Identification and characterization of the rhp23(+) DNA repair gene in Schizosaccharomyces pombe.
Biochemical and biophysical research communications - 5 Feb 2000
Lombaerts M, Goeloe J I, den Dulk H, Brandsma J A, Brouwer J
Abstract excerpt
We have identified rhp23(+), the ortholog of the Saccharomyces cerevisiae RAD23 and human HHR23A and HHR23B genes, in Schizosaccharomyces pombe and examined its role in cell survival and DNA repair. In S. pombe two repair mechanisms are operative on UV-induced photoproducts, i.e., UV damage repair (UVDR) and nucleotide excision repair (NER). Here we show that Rhp23 is solely involved in NER and study its role in...
Topics
- Amino Acid Sequence
- Base Sequence
- DNA Primers
- DNA Repair
- DNA Repair Enzymes
- DNA-Binding Proteins
- Fungal Proteins
- Gene Expression
- Genes, Fungal
- Genetic Complementation Test
- Humans
- Molecular Sequence Data
- Mutation
- Saccharomyces cerevisiae