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Article

Yeast RAD14 and human xeroderma pigmentosum group A DNA-repair genes encode homologous proteins.

Nature - 6 Feb 1992

Bankmann M, Prakash L, Prakash S

Abstract excerpt

Xeroderma pigmentosum (XP), a human autosomal recessive disorder, is characterized by extreme sensitivity to sunlight and high incidence of skin cancers. XP cells are defective in the incision step of excision repair of DNA damaged by ultraviolet light. Cell fusion studies have defined seven XP complementation groups, XP-A to XP-G. Similar genetic complexity of excision repair is observed in the yeast...

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Source

Identifiers

PMID: 1741034
DOI: 10.1038/355555a0

Genes

RAD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Yeast RAD14 and human xeroderma pigmentosum group A DNA-repair genes encode homologous proteins.PMID 1741034Read ↗

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Complex formation with damage recognition protein Rad14 is essential for Saccharomyces cerevisiae Rad1-Rad10 nuclease to perform its function in nucleotide excision repair in vivo.Semantic proximity Read ↗

Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis.Semantic proximity Read ↗

Spotlight on 'xeroderma pigmentosum'.Semantic proximity Read ↗

Physical and functional interactions between nucleotide excision repair and DNA damage checkpoint.Semantic proximity Read ↗

Overview of xeroderma pigmentosum proteins architecture, mutations and post-translational modifications.Semantic proximity Read ↗

True XP group E patients have a defective UV-damaged DNA binding protein complex and mutations in DDB2 which reveal the functional domains of its p48 product.Semantic proximity Read ↗

A fragment of the yeast DNA repair protein Rad4 confers toxicity to E. coli and is required for its interaction with Rad7 protein.Semantic proximity Read ↗

Allelism of PSO4 and PRP19 links pre-mRNA processing with recombination and error-prone DNA repair in Saccharomyces cerevisiae.Semantic proximity Read ↗

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Genetic analysis of the Neurospora crassa RAD14 homolog mus-43 and the RAD10 homolog mus-44 reveals that they belong to the mus-38 pathway of two nucleotide excision repair systems.Semantic proximity Read ↗

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