Article
A mutation in repB, the dictyostelium homolog of the human xeroderma pigmentosum B gene, has increased sensitivity to UV-light but normal morphogenesis.
Biochimica et biophysica acta - 20 Aug 1998
Lee S K, Yu S L, Alexander H, Alexander S
Abstract excerpt
Nucleotide excision repair (NER) is an important cellular defense mechanism which protects the integrity of the genome by removing DNA damage caused by UV-light or chemical agents. In humans, defects in the NER pathway result in the disease xeroderma pigmentosum (XP) which is characterized by inc...
Topics
- Amino Acid Sequence
- Animals
- Bacterial Proteins
- Blotting, Northern
- Blotting, Southern
- DNA Helicases
- DNA Repair
- DNA-Binding Proteins
- Dictyostelium
- Gene Deletion
- Molecular Sequence Data
- Mutation
- Plasmids
- RNA, Messenger
- Restriction Mapping
- Sequence Alignment
- Ultraviolet Rays
- Xeroderma Pigmentosum