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Article

Involvement of Schizosaccharomyces pombe Srs2 in cellular responses to DNA damage.

Nucleic acids research - 15 Jul 2001

Wang S W, Goodwin A, Hickson I D, Norbury C J

Abstract excerpt

In the budding yeast Saccharomyces cerevisiae the Srs2/RadH DNA helicase promotes survival after ultraviolet (UV) irradiation, and has been implicated in DNA repair, recombination and checkpoint signalling following DNA damage. A second helicase, Sgs1, is the S.cerevisiae homologue of the human BLM and WRN proteins, which are defective in cancer predisposition and/or premature ageing syndromes. Saccharomyces...

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Source

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Identifiers

PMID: 11452021
DOI: 10.1093/nar/29.14.2963
PMCID: PMC55813

Genes

BLM
WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Involvement of Schizosaccharomyces pombe Srs2 in cellular responses to DNA damage.PMID 11452021Read ↗

Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases.Semantic proximity Read ↗

The severe slow growth of Deltasrs2 Deltarqh1 in Schizosaccharomyces pombe is suppressed by loss of recombination and checkpoint genes.Semantic proximity Read ↗

Requirement of yeast SGS1 and SRS2 genes for replication and transcription.Semantic proximity Read ↗

The human F-Box DNA helicase FBH1 faces Saccharomyces cerevisiae Srs2 and postreplication repair pathway roles.Semantic proximity Read ↗

The srs2 suppressor of UV sensitivity acts specifically on the RAD5- and MMS2-dependent branch of the RAD6 pathway.Semantic proximity Read ↗

Maintenance of Yeast Genome Integrity by RecQ Family DNA Helicases.Semantic proximity Read ↗

Redundant roles of Srs2 helicase and replication checkpoint in survival and rDNA maintenance in Schizosaccharomyces pombe.Semantic proximity Read ↗

Genetic analysis of the Saccharomyces cerevisiae Sgs1 helicase defines an essential function for the Sgs1-Top3 complex in the absence of SRS2 or TOP1.Semantic proximity Read ↗

Requirement of Rrm3 helicase for repair of spontaneous DNA lesions in cells lacking Srs2 or Sgs1 helicase.Semantic proximity Read ↗

Role of Blm and collaborating factors in recombination and survival following replication stress in Ustilago maydis.Semantic proximity Read ↗

Requirement for the SRS2 DNA helicase gene in non-homologous end joining in yeast.Semantic proximity Read ↗

Coordinated functions of WSS1, PSY2 and TOF1 in the DNA damage response.Semantic proximity Read ↗

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