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Article

Additive roles of XPA and MSH2 genes in UVB-induced skin tumorigenesis in mice.

DNA repair - 3 Nov 2002

Yoshino Masafumi, Nakatsu Yoshimichi, te Riele Hein, Hirota Seiichi, Kitamura Yukihiko, Tanaka Kiyoji

Abstract excerpt

We have made xeroderma pigmentosum group A gene (XPA)-knockout mice (XPA(-/-) mice). The XPA(-/-) mice had no detectable activity for nucleotide excision repair (NER) and showed a high incidence of UVB-induced skin tumorigenesis. We have also found that cell lines derived from skin cancers in UVB-irradiated XPA(-/-) mice become tolerant to UV-irradiation and showed abnormal UV-induced cell cycle checkpoints and...

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Source

Identifiers

PMID: 12531021
DOI: 10.1016/s1568-7864(02)00144-1

Genes

XPA
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Additive roles of XPA and MSH2 genes in UVB-induced skin tumorigenesis in mice.PMID 12531021Read ↗

UV-induced skin carcinogenesis in xeroderma pigmentosum group A (XPA) gene-knockout mice with nucleotide excision repair-deficiency.Semantic proximity Read ↗

Decreased UV sensitivity, mismatch repair activity and abnormal cell cycle checkpoints in skin cancer cell lines derived from UVB-irradiated XPA-deficient mice.Semantic proximity Read ↗

Mouse models for xeroderma pigmentosum group A and group C show divergent cancer phenotypes.Semantic proximity Read ↗

Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA.Semantic proximity Read ↗

The role of altered nucleotide excision repair and UVB-induced DNA damage in melanomagenesis.Semantic proximity Read ↗

Relative susceptibilities of XPA knockout mice and their heterozygous and wild-type littermates to UVB-induced skin cancer.Semantic proximity Read ↗

DDB2 gene disruption leads to skin tumors and resistance to apoptosis after exposure to ultraviolet light but not a chemical carcinogenSemantic proximity Read ↗

Mice defective in the mismatch repair gene Msh2 show increased predisposition to UVB radiation-induced skin cancer.Semantic proximity Read ↗

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DNA repair-deficient Xpa and Xpa/p53+/- knock-out mice: nature of the models.Semantic proximity Read ↗

Differential role of transcription-coupled repair in UVB-induced G 2 arrest and apoptosis in mouse epidermisSemantic proximity Read ↗

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