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Mice defective in the mismatch repair gene Msh2 show increased predisposition to UVB radiation-induced skin cancer.

DNA repair - 3 Nov 2002

Meira Lisiane B, Cheo David L, Reis Antonio M, Claij Nanna, Burns Dennis K, te Riele Hein, Friedberg Errol C

Abstract excerpt

Mice defective in the mismatch repair (MMR) gene Msh2 manifest an enhanced predisposition to skin cancer associated with exposure to UVB radiation. This predisposition is further heightened if the mice are additionally defective for the nucleotide excision repair gene Xpc. To test the hypothesis that the predisposition of Msh2 mutant mice to skin cancer reflects a mutator phenotype associated with increased...

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Identifiers

PMID: 12531020
DOI: 10.1016/s1568-7864(02)00143-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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