DNA structure dependent checkpoints as regulators of DNA repair.

Abstract excerpt

Checkpoint proteins were initially identified because their loss of function resulted in defects in cell cycle arrest in response to genotoxic treatments. Initially, the analysis of checkpoint pathways concentrated on their function as signal transducers and how the checkpoint signals were communicated to the core cell cycle machinery and transcriptional apparatus. Although some of the early genetic analysis...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Checkpoint Kinase 2
• Share to DNA Replication
• Share to Endonucleases