DNMT1 gene copy number does not influence susceptibility to development of malignant lymphoproliferative disease.

Abstract excerpt

BACKGROUND: For many years, the methylating enzyme DNMT1 has been thought to critically influence neoplastic transformation. To determine if DNMT1 is involved in the early events of malignant transformation of lymphoid cells, we investigated whether allele-specific variation in the gene copy number of DNMT1 influences susceptibility to the development of malignant lymphoproliferative disease (LPD) associated with...

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