A novel MspI PCR-RFLP in the human cytosine 5-methyltransferase gene: lack of relevance for malignant lymphoproliferative disease and breast cancer.

doi:10.1159/000022805

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Article

A novel MspI PCR-RFLP in the human cytosine 5-methyltransferase gene: lack of relevance for malignant lymphoproliferative disease and breast cancer.

Human heredity - 1 Jan 2000

Bagwe A N, Ahmed M O, Franchina M, Spagnolo D V, Papadimitriou J M, Kay P H

Abstract excerpt

Two alternate allelic forms of human cytosine 5-methyltransferase, 5-MT I and 5-MT II, which differ by the absence or presence of an intronic MspI recognition sequence, have been recognised. The polymorphic region was localised using a series of subprobes prepared upon MspI digestion of the 2.5-k...

Topics

Alleles
Breast Neoplasms
DNA (Cytosine-5-)-Methyltransferases
DNA-Cytosine Methylases
Deoxyribonucleases, Type II Site-Specific
Female
Gene Dosage
Gene Frequency
Humans
Introns
Lymphoma, Non-Hodgkin

Male

Phenotype

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

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