Increased DNA methyltransferase 1 (DNMT1) gene expression in human lymphomas by fluorescent in situ hybridization.

Abstract excerpt

BACKGROUND: The DNA Methyltransferase 1 (DNMTI) gene is among the better known 'epigenetic' systems that can regulate normal and abnormal gene expression as well as create 'hot spots' for DNA mutations. Its role has been studied in a number of malignancies with important implications for involvement in early events of malignant transformation. The present study describes the findings with respect to expression of...

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