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CD34<sup>−</sup>Hematopoietic Stem Cells: Current Concepts and Controversies

1 Jan 2003

Abstract excerpt

Recent data have suggested that human CD34(-) hematopoietic stem cells (HSCs) exist, challenging the concept that HSCs necessarily and exclusively express the CD34 antigen. In mice, quiescent HSCs have been shown to be mostly CD34(-), but as a consequence of 5-fluorouracil treatment or cytokine stimulation, differentiate into CD34(+) cells. Of particular interest is a novel, specific marker to identify HSCs,...

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PMID: 12529547
DOI: 10.1634/stemcells.21-1-15

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