Article
Phenotypic and functional reversal within the early human hematopoietic compartment.
Stem cells (Dayton, Ohio) - 1 Dec 2008
Knaän-Shanzer Shoshan, van der Velde-van Dijke Ietje, van de Watering Marloes J M, de Leeuw Philip J, Valerio Dinko, van Bekkum Dirk W, de Vries Antoine A F
Abstract excerpt
The fate of phenotypically defined human hematopoietic stem cells (hHSCs) in culture and the link between their surface marker expression profile and function are still controversial. We studied these aspects of hHSC biology by relating the expression of the early lineage markers (ELM) CD33, CD38, and CD71 on the surface of human umbilical cord blood (UCB) CD34(+) cells to their long-term nonobese diabetic/severe...
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