Article
Identification and isolation of hematopoietic stem cells.
Archives of medical research - 1 Jan 2000
Wognum Albertus W, Eaves Allen C, Thomas Terry E
Abstract excerpt
Hematopoietic stem cells (HSCs) are defined by their ability to repopulate all of the hematopoietic lineages in vivo and sustain the production of these cells for the life span of the individual. In the absence of reliable direct markers for HSCs, their identification and enumeration depends on functional long-term, multilineage, in vivo repopulation assays. The extremely low frequency of HSCs in any tissue and...
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