Article
Isolation and clonal characterization of hematopoietic and liver stem cells.
Cornea - 1 Nov 2004
Nakauchi Hiromitsu
Abstract excerpt
PURPOSE: Prospective isolation of stem cells is essential to understanding the mechanisms that control their proliferation and differentiation. METHODS AND RESULTS: Using 9 monoclonal antibodies and fluorescence-activated cell sorting (FACS), we have succeeded in prospectively identifying hematopoietic stem cells (HSCs) in adult mouse bone marrow. Mouse HSCs were exclusively enriched in CD34 negative, c-Kit Sca-1...
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