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Article

Cellular uptake of Antennapedia Penetratin peptides is a two-step process in which phase transfer precedes a tryptophan-dependent translocation.

Nucleic acids research - 15 Jan 2003

Dom Geneviève, Shaw-Jackson Chloë, Matis Christelle, Bouffioux Olivier, Picard Jacques J, Prochiantz Alain, Mingeot-Leclercq Marie-Paule, Brasseur Robert, Rezsohazy René

Abstract excerpt

Several homeodomains and homeodomain-containing proteins enter live cells through a receptor- and energy-independent mechanism. Translocation through biological membranes is conferred by the third alpha-helix of the homeodomain, also known as Penetratin. Biophysical studies demonstrate that entry of Penetratin into cells requires its binding to surface lipids but that binding and translocation are differentially...

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PMID: 12527762
DOI: 10.1093/nar/gkg160
PMCID: PMC140524

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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