Article
Lipid and phase specificity of α-toxin from S. aureus.
Biochimica et biophysica acta - 1 Aug 2013
Schwiering M, Brack A, Stork R, Hellmann N
Abstract excerpt
The pore forming toxin Hla (α-toxin) from Staphylococcus aureus is an important pathogenic factor of the bacterium S. aureus and also a model system for the process of membrane-induced protein oligomerisation and pore formation. It has been shown that binding to lipid membranes at neutral or basic pH requires the presence of a phosphocholine-headgroup. Thus, sphingomyelin and phosphatidylcholine may serve as...
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