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Article

Hierarchical modeling of linkage disequilibrium: genetic structure and spatial relations.

American journal of human genetics - 1 Feb 2003

Conti David V, Witte John S

Abstract excerpt

Linkage disequilibrium (LD) mapping offers much promise for the positional cloning of disease-causing genes. However, conventional estimates of LD may fluctuate substantially across contiguous genomic regions, because of population-specific phenomena such as mutation, genetic drift, population structure, and variations in allele frequencies. This fluctuation makes it difficult to interpret patterns of LD and...

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Identifiers

PMID: 12525994
DOI: 10.1086/346117
PMCID: PMC379228

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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