Article
A comparison of linkage disequilibrium measures for fine-scale mapping.
Genomics - 20 Sept 1995
Devlin B, Risch N
Abstract excerpt
Linkage mapping generally localizes disease genes to 1- to 2-cM regions of chromosomes. In theory, further refinement of location can be achieved by population-based studies of linkage disequilibrium between disease locus alleles and alleles at adjacent markers. One approach to localization, dubb...
Topics
- Alleles
- Biological Evolution
- Case-Control Studies
- Chromosome Mapping
- Genetic Diseases, Inborn
- Genetic Markers
- Haplotypes
- Humans
- Linkage Disequilibrium
- Models, Genetic
- Models, Statistical
- Sensitivity and Specificity
- Stochastic Processes