Article
A comparison of linkage disequilibrium measures for fine-scale mapping.
Genomics - 20 Sept 1995
Devlin B, Risch N
Abstract excerpt
Linkage mapping generally localizes disease genes to 1- to 2-cM regions of chromosomes. In theory, further refinement of location can be achieved by population-based studies of linkage disequilibrium between disease locus alleles and alleles at adjacent markers. One approach to localization, dubbed simple disequilibrium mapping, is to determine the relative location of the disease locus by plotting disequilibrium...
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