Article
A spatial probit model for fine-scale mapping of disease genes.
Genetic epidemiology - 1 Apr 2007
De Iorio Maria, Verzilli Claudio J
Abstract excerpt
We present a novel statistical method for linkage disequilibrium (LD) mapping of disease susceptibility loci in case-control studies. Such studies exploit the statistical correlation or LD that exist between variants physically close along the genome to identify those that correlate with disease status and might thus be close to a causative mutation, generally assumed unobserved. LD structure, however, varies...
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