Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Haplotype fine mapping by evolutionary trees.

American journal of human genetics - 1 Feb 2000

Lam J C, Roeder K, Devlin B

Abstract excerpt

To refine the location of a disease gene within the bounds provided by linkage analysis, many scientists use the pattern of linkage disequilibrium between the disease allele and alleles at nearby markers. We describe a method that seeks to refine location by analysis of "disease" and "normal" haplotypes, thereby using multivariate information about linkage disequilibrium. Under the assumption that the disease...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Tandem Repeat Sequences
Share to Statistics, Nonparametric
Share to Genetic Diseases, Inborn

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Heterogeneity

Share to Hemochromatosis

Share to Hemochromatosis Protein

Share to Histocompatibility Antigens Class I

Share to Likelihood Functions

Source

Open in PubMed Open full text

Identifiers

PMID: 10677324
DOI: 10.1086/302756
PMCID: PMC1288117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Haplotype fine mapping by evolutionary trees.PMID 10677324Read ↗

Fine mapping of disease genes via haplotype clustering.Semantic proximity Read ↗

Fine-scale mapping of disease genes with multiple mutations via spatial clustering techniques.Semantic proximity Read ↗

Mapping trait loci by use of inferred ancestral recombination graphs.Semantic proximity Read ↗

Classifying disease chromosomes arising from multiple founders, with application to fine-scale haplotype mapping.Semantic proximity Read ↗

Fine mapping--19th century style.Semantic proximity Read ↗

GERBIL: Genotype resolution and block identification using likelihood.Semantic proximity Read ↗

A hidden markov model combining linkage and linkage disequilibrium information for haplotype reconstruction and quantitative trait locus fine mapping.Semantic proximity Read ↗

Association mapping of complex diseases with ancestral recombination graphs: models and efficient algorithms.Semantic proximity Read ↗

Coalescent methods for fine-scale disease-gene mapping.Semantic proximity Read ↗

Fine mapping of disease genes using tagging SNPs.Semantic proximity Read ↗

Fine-scale mapping using Hardy-Weinberg disequilibrium.Semantic proximity Read ↗

Fine-scale mapping of disease loci via shattered coalescent modeling of genealogies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.