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Article

High-frequency phenotypic reversion and pathogenicity of an acyclovir-resistant herpes simplex virus mutant.

Journal of virology - 1 Feb 2003

Griffiths Anthony, Coen Donald M

Abstract excerpt

A double-guanine-insertion mutation within a run of guanines in the herpes simplex virus gene encoding thymidine kinase (TK) was previously found in an acyclovir-resistant clinical isolate. This mutation was engineered into strain KOS, and stocks were generated from single plaques. Plaque autoradiography revealed that most plaques in such stocks exhibited low levels of TK activity, while approximately 3% of...

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Share to Acyclovir
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Recombination, Genetic

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Source

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Identifiers

PMID: 12525666
DOI: 10.1128/jvi.77.3.2282-2286.2003
PMCID: PMC140925

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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