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Article

Penciclovir and pathogenesis phenotypes of drug-resistant Herpes simplex virus mutants.

Antiviral research - 1 Jan 1998

Pelosi E, Mulamba G B, Coen D M

Abstract excerpt

We compared the penciclovir susceptibilities and pathogenesis phenotypes of mutants of Herpes simplex virus type 1 that are resistant to acyclovir and/or foscarnet. The mutants, which were derived from laboratory strain KOS, included six DNA polymerase mutants, a thymidine kinase negative mutant, a thymidine kinase partial mutant, and a double mutant. Two of four polymerase mutants not previously examined for...

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PMID: 9497069
DOI: 10.1016/s0166-3542(97)00054-5

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