Penciclovir and pathogenesis phenotypes of drug-resistant Herpes simplex virus mutants.

doi:10.1016/s0166-3542(97)00054-5

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Article

Penciclovir and pathogenesis phenotypes of drug-resistant Herpes simplex virus mutants.

Antiviral research - 1 Jan 1998

Pelosi E, Mulamba G B, Coen D M

Abstract excerpt

We compared the penciclovir susceptibilities and pathogenesis phenotypes of mutants of Herpes simplex virus type 1 that are resistant to acyclovir and/or foscarnet. The mutants, which were derived from laboratory strain KOS, included six DNA polymerase mutants, a thymidine kinase negative mutant,...

Topics

Acyclovir
Animals
Antiviral Agents
Chlorocebus aethiops
Cornea
Drug Resistance, Microbial
Genes, pol
Guanine
Herpes Simplex
Herpesvirus 1, Human
Mice
Mutation
Phenotype
Thymidine Kinase
Trigeminal Ganglion
Vero Cells
Viral Plaque Assay
Virulence

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