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Article

Difference in incidence of spontaneous mutations between Herpes simplex virus types 1 and 2.

Antimicrobial agents and chemotherapy - 1 Jun 2000

Sarisky R T, Nguyen T T, Duffy K E, Wittrock R J, Leary J J

Abstract excerpt

Spontaneous mutations within the herpes simplex virus (HSV) genome are introduced by errors during DNA replication. Indicative of the inherent mutation rate of HSV DNA replication, heterogeneous HSV populations containing both acyclovir (ACV)-resistant and ACV-sensitive viruses occur naturally in both clinical isolates and laboratory stocks. Wild-type, laboratory-adapted HSV type 1 (HSV-1) strains KOS and Cl101...

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Identifiers

PMID: 10817703
DOI: 10.1128/AAC.44.6.1524-1529.2000
PMCID: PMC89907

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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