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Article

Phenotypic and genotypic characterization of clinical isolates of herpes simplex virus resistant to aciclovir.

The Journal of general virology - 1 Jun 2003

Harris Wendy, Collins Peter, Fenton Rob J, Snowden Wendy, Sowa Mike, Darby Graham

Abstract excerpt

A panel of 10 clinical isolates of herpes simplex virus (HSV) deficient in the expression of thymidine kinase (TK) and phenotypically resistant to aciclovir was characterized. Sequence analysis revealed a variety of mutations in TK (nucleotide substitutions, insertions and deletions), most of which resulted in truncated TK polypeptides. In line with previous reports, the most common mutation was a single G...

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Identifiers

PMID: 12771406
DOI: 10.1099/vir.0.18880-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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