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Article

Recurrent Acyclovir‐Resistant Herpes Simplex in an Immunocompromised Patient: Can Strain Differences Compensate for Loss of Thymidine Kinase in Pathogenesis?

1 Sept 1998

Abstract excerpt

To investigate how acyclovir-resistant (ACVr) herpes simplex virus (HSV) evades drug therapy and causes disease, HSV-1 isolates from a bone marrow transplant (BMT) patient were studied. The patient developed ACVr disease after an initial BMT and, following a second BMT, reactivated ACVr HSV despite high-dose acyclovir prophylaxis. ACVr isolates from each episode contained the same point mutation in the viral...

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PMID: 9728528
DOI: 10.1086/515375

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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