Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of a neurovirulent aciclovir-resistant variant of herpes simplex virus.

The Journal of general virology - 1 Jun 2003

Grey Finn, Sowa Mike, Collins Peter, Fenton Rob J, Harris Wendy, Snowden Wendy, Efstathiou Stacey, Darby Graham

Abstract excerpt

A clinical isolate of herpes simplex virus type 1 that is aciclovir resistant but neurovirulent in mice was described previously. The mutation in this virus is a double G insertion in a run of seven G residues that has been shown previously to be a mutational hotspot. Using a sensitive assay, it has been demonstrated that preparations of this virus are able to induce low but consistent levels of thymidine kinase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acyclovir
Share to Chlorocebus aethiops

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Frameshift Mutation

Share to Herpes Simplex

Share to Herpesvirus 1, Human

Share to Protein Biosynthesis

Share to Thymidine Kinase

Share to Vero Cells

Source

Identifiers

PMID: 12771407
DOI: 10.1099/vir.0.18881-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of a neurovirulent aciclovir-resistant variant of herpes simplex virus.PMID 12771407Read ↗

Phenotypic and genotypic characterization of clinical isolates of herpes simplex virus resistant to aciclovir.Semantic proximity Read ↗

Characterization of DNA polymerase-associated acyclovir-resistant herpes simplex virus type 1: mutations, sensitivity to antiviral compounds, neurovirulence, and in-vivo sensitivity to treatment.Semantic proximity Read ↗

In vitro and in vivo characterization of herpes simplex virus clinical isolates recovered from patients infected with human immunodeficiency virus.Semantic proximity Read ↗

Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus.Semantic proximity Read ↗

Acyclovir-resistant, pathogenic herpesviruses.Semantic proximity Read ↗

Diverse Herpes Simplex Virus Type 1 Thymidine Kinase Mutants in Individual Human Neurons and GangliaSemantic proximity Read ↗

Latent acyclovir-resistant herpes simplex virus type 1 in trigeminal ganglia of immunocompetent individuals.Semantic proximity Read ↗

High-frequency phenotypic reversion and pathogenicity of an acyclovir-resistant herpes simplex virus mutant.Semantic proximity Read ↗

Expression of extremely low levels of thymidine kinase from an acyclovir-resistant herpes simplex virus mutant supports reactivation from latently infected mouse trigeminal ganglia.Semantic proximity Read ↗

Identification and characterization of acyclovir-resistant clinical HSV-1 isolates from children.Semantic proximity Read ↗

Penciclovir and pathogenesis phenotypes of drug-resistant Herpes simplex virus mutants.Semantic proximity Read ↗

Genotypic and phenotypic characterization of the thymidine kinase of ACV-resistant HSV-1 derived from an acyclovir-sensitive herpes simplex virus type 1 strain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.