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Article

Anthrax lethal factor proteolysis and inactivation of MAPK kinase.

The Journal of biological chemistry - 14 Mar 2003

Chopra Arun P, Boone Sherrie A, Liang Xudong, Duesbery Nicholas S

Abstract excerpt

Anthrax lethal toxin produced by the bacterium Bacillus anthracis is the major cause of death in animals infected with anthrax. One component of this toxin, lethal factor (LF), inactivates members of the mitogen-activated protein kinase kinase or MEK family through proteolysis of their NH(2) termini. However, neither the substrate requirements for LF cleavage nor the mechanism by which proteolysis inactivates MEK...

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Identifiers

PMID: 12522135
DOI: 10.1074/jbc.M211262200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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