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Article

Tyrosine-728 and glutamic acid-735 are essential for the metalloproteolytic activity of the lethal factor of Bacillus anthracis.

Biochemical and biophysical research communications - 16 Jan 2004

Tonello Fiorella, Naletto Laura, Romanello Vanina, Dal Molin Federica, Montecucco Cesare

Abstract excerpt

The lethal factor (LF) of Bacillus anthracis is a Zn2+-endopeptidase specific for the MAPK-kinase family of proteins. The catalytic zinc atom is coordinated by a first shell of residues including the two histidines and the glutamate of the zinc-binding motif HExxH and by Glu-735. A characteristic feature of LF is the presence, within the second shell of residues, of a tyrosine (Tyr-728) in close proximity (3.3 A)...

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PMID: 14697216
DOI: 10.1016/j.bbrc.2003.11.134

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